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pentobarbital will lessen the level or impact of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic result of elbasvir/grazoprevir could be minimized if coadministered with solid CYP3A inducers and it is thus contraindicated.pentobarbital decreases amounts of vandetanib by impacting hepat